Lab-visit: Proteomics & Genomics

Recently the group Integrative genomics and Proteomics moved to a shared location with an up-to-date laboratory. The central aim of the Integrative Genomics research group is to do functional genetic studies for multiple diseases including diabetes and cardiovascular diseases. In this research whe make use of multiple genetic tools and equipment. One of those technique is genotyping with single nucleotide polymorphisms (SNPs) to study candidate genes and to identify novel genes involved in complex disease. Also gene-expression is done by investigating the activation of multiple genes that are involved. After this, statistical analyses are done to detect associations with the genotyping or gene-expression. Possible candidate genes will be analyzed by doing functional studies in animals by knocking out the genes.

The Proteomics facility aims to develop and exploit protein detection platforms that allow the (rapid) analysis of large numbers of clinical samples, which is necessary to establish a statistically significant link between e.g. disease development and changes in protein patterns. The instrumentation of the facility is based on the latest developments in proteomics techniques that provide more rapid and automated, integrated analytical platforms and are suitable for research into molecular mechanisms of disease and biomarker identification